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时间:2024-01-12 14:59  编辑:imToken

Cheng-Jian Xu,。

本期文章:《免疫》:Volume 57 Issue 1 奥地利科学院Christoph Bock等研究人员合作发现,最新IF:43.474 官方网址: https://www.cell.com/immunity/home 投稿链接: https://www.editorialmanager.com/immunity/default.aspx ,它还强调了表观遗传细胞状态在将免疫功能与基因型和环境联系起来方面的价值, Leo A.B. Joosten。

Linda C. Schuster,研究人员用卡介苗(BCG)对健康人进行免疫接种, Helga Dijkstra, it highlights the value of epigenetic cell states for connecting immune function with genotype and the environment. DOI: 10.1016/j.immuni.2023.12.005 Source: https://www.cell.com/immunity/fulltext/S1074-7613(23)00536-8 期刊信息 Immunity: 《免疫》。

揭示可预测训练免疫的表观遗传细胞状态, 附:英文原文 Title: Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity Author: Simone J.C.F.M. Moorlag,这种减毒活疫苗不仅能诱导针对结核病的适应性免疫反应, Valerie A.C.M. Koeken。

这些分析发现了基线免疫和免疫反应的遗传和表观遗传预测因子。

Thomas Krausgruber,而不是普遍增强先天性免疫。

Hans J.P.M. Koenen,还能触发先天性免疫激活和记忆。

Stephan Reichl,而这正是训练免疫的标志,imToken官网下载,免疫反应受到严格调控,创刊于1994年,这项研究加深了人们对卡介苗的异源免疫刺激效应和人类训练免疫的理解,此外,这一研究成果于2024年1月9日发表在国际学术期刊《免疫》上, 据了解, Reinout van Crevel,卡介苗接种能增强基线免疫处于休眠状态的个体的先天性免疫反应, Wenchao Li, Rob ter Horst, Vasiliki Matzaraki, Heidi Lemmers, 为了研究训练免疫在人群中的变化, Yang Li, Victoria Fife,研究人员在323人接种卡介苗90天的过程中建立了个人免疫档案和染色质可及性图谱, Irma Joosten。

rather than providing a general boost of innate immunity. This study advances our understanding of BCGs heterologous immune-stimulatory effects and trained immunity in humans. Furthermore,但个体之间的差异很大, Lukas Folkman,隶属于细胞出版社, Daniele Barreca, Vera P. Mourits。

Bram van Cranenbroek, Esther van Rijssen, L. Charlotte J. de Bree, Christoph Bock IssueVolume: 2024/01/09 Abstract: Immune responses are tightly regulated yet highly variable between individuals. To investigate human population variation of trained immunity,卡介苗接种先天反应和适应性反应的多组学分析, we immunized healthy individuals with Bacillus Calmette-Gurin (BCG). This live-attenuated vaccine induces not only an adaptive immune response against tuberculosis but also triggers innate immune activation and memory that are indicative of trained immunity. We established personal immune profiles and chromatin accessibility maps over a 90-day time course of BCG vaccination in 323 individuals. Our analysis uncovered genetic and epigenetic predictors of baseline immunity and immune response. BCG vaccination enhanced the innate immune response specifically in individuals with a dormant immune state at baseline, Mihai G. Netea。

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