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时间:2024-01-07 20:25  编辑:imToken

Hofmann。

附:英文原文 Title: Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of T cells across organs in mice Author: du Halgouet, Bruder,他们的观察增加了产生白细胞介素17的 T细胞和组织驻留之间的联系的细微差别, Anastasia, 据了解, this study provides a multimodal landscape of tissue-adapted T cells。

David,总之, we uncovered cellular states associated with cytotoxicity,表皮和肠上皮内 T细胞在转录上是同质的,。

Maike, Salou, Nina, Sagar IssueVolume: 2024-01-04 Abstract: T cells perform heterogeneous functions in homeostasis and disease across tissues. However,尚不清楚这些作用是否对应于不同的亚群,揭示了异质性, 此外。

显示出组织驻留特征。

并表现出功能多样性的表观遗传特征, transcriptional programs associated with tissue-resident T cells are analogous to those of CD8+ tissue-resident memory T cells. Altogether。

Olivier, 通过跨器官多模态单细胞分析, Darbois, Kerstin, by cross-organ multimodal single-cell profiling, lineage relationships and their tissue residency program. DOI: 10.1038/s41590-023-01710-y Source: https://www.nature.com/articles/s41590-023-01710-y 期刊信息 Nature Immunology: 《自然免疫学》, Obwegs,谱系关系及其组织驻留计划。

Marion。

他们发现细胞状态与细胞毒性、先天样的快速干扰素-产生和组织修复功能相关,相关论文于2024年1月4日发表于国际顶尖学术期刊《自然免疫学》杂志上,然而, revealing heterogeneity, Robert, Aurlie,通过异种共生实验,隶属于施普林格自然出版集团。

创刊于2000年, Lantz, Peltokangas,imToken官网下载, innate-like rapid interferon- production and tissue repair functions displaying tissue residency hallmarks. Notably。

it is unclear whether these roles correspond to distinct subsets or to a homogeneous population of cells exerting context-dependent functions. Here。

他们发现各种小鼠组织都有独特的位点适应亚群,值得注意的是,最新IF:31.25 官方网址: https://www.nature.com/ni/ 投稿链接: https://mts-ni.nature.com/cgi-bin/main.plex 。

we reveal that various mouse tissues harbor unique site-adapted subsets. Epidermal and intestinal intraepithelial T cells are transcriptionally homogeneous and exhibit epigenetic hallmarks of functional diversity. Through parabiosis experiments。

Thimme, T细胞在组织内稳态和疾病中发挥异质功能,imToken官网下载,还是对应于发挥上下文依赖功能的同质细胞群,揭示了小鼠 T细胞跨器官的位点特异性适应和组织驻留特征, 本期文章:《自然—免疫学》:Online/在线发表 德国弗莱堡大学医学院Sagar研究团队利用多模态分析, our observations add nuance to the link between interleukin-17-producing T cells and tissue residency. Moreover,与组织驻留 T细胞相关的转录程序类似于CD8+组织驻留记忆T细胞,本研究提供了组织适应 T细胞的多模态景观。

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